Granzyme B, Mouse
產(chǎn)品名稱： Granzyme B, Mouse
英文名稱：
產(chǎn)品編號(hào)： CB055-1542
產(chǎn)品價(jià)格： 0
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： ExCell Bio
更新時(shí)間： null
使用范圍： null
上海吉泰依科賽生物科技有限公司
- 聯(lián)系人 :
- 地址 : 上海市徐匯區(qū)桂平路481號(hào)18號(hào)樓5層
- 郵編 : 200233
- 所在區(qū)域 : 上海
- 電話 : 021-6439-8855 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : marketing@excellbio.com
Granzyme B is a serine protease most commonly found in the granules of cytotoxic lymphocytes (CTLs), natural killer cells (NK cells) and cytotoxic T cells. It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells.
Granzyme B has also recently been found to be produced by a wide range of non-cytotoxic cells ranging from basophils and mast cells to smooth muscle cells. The secondary functions of granzyme B are also numerous. Granzyme B has been shown to be involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodeling.
Recombinant Mouse Granzyme B produced in CHO cells is a polypeptide chain containing 227 amino acids. A fully biologically active molecule, rmGranzyme B has a molecular mass of 32 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at ExCell Bio.