Rabbit anti-human Bone marrow stromal antigen 2 polyclonal Antibody(BST2 )
產品名稱： Rabbit anti-human Bone marrow stromal antigen 2 polyclonal Antibody(BST2 )
英文名稱：
產品編號： CSB-PA606010DSR2HU
產品價格： null
產品產地： CN
品牌商標： CUSABIO
更新時間： null
使用范圍： ELISA,IHC;Recommended dilution:IHC:1:20-1:200
武漢華美生物工程有限公司
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Uniprot ID:Q10589 Species Reactivity:Human Antibody type:Polyclonal Antibody Aliases:BST-2,HM1.24 antigen,Tetherin,BST2Raised in:Rabbit Background\Function :IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities. Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu. Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2. Stroage Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Purity:Antigen Affinity Purified 武漢華美生物工程有限公司專營基因、蛋白、抗體、ELISA試劑盒、診斷試劑原料、藥物殘留、食品安全小分子及其他小分子等高質量生物產品，我們的產品涉及血管生成、細胞凋亡/自噬、合成/代謝、血液凝固、細胞粘附、細胞周期、補體、發育蛋白、DNA損傷/DNA修復、細胞因子、藥物殘留與食品安全、受精作用、生長因子、神經生物學、氧化應激、信息受體、轉錄/轉錄調控、運輸、泛素、信號傳導通路、自身免疫等多個研究領域，包括涵蓋37個種屬的多達萬種的ELISA試劑盒。詳細信息請登錄：www.cusabio.cn/