Recombinant Human IL-1α
 
Catalog Number:
AF-200-01A
Synonyms:
Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte, Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Description:
IL-1α是一個非分泌促炎性細胞因子，可由多種細胞，包括單核細胞，組織巨噬細胞，角質形成細胞和其他上皮細胞產生。IL-1α和IL-1β結合同一受體，并具有類似的，即使不是完全相同的的生物學特性。這些細胞因子有廣泛的活性，包括刺激胸腺細胞增殖，誘導IL-2釋放，B細胞的成熟和增殖，FGF樣的促有絲分裂活性以及刺激滑膜細胞釋放前列腺素和膠原酶。 相反，IL-1β是一種分泌型的細胞因子。重組人IL-1α是一個分子量為18.0 kDa的蛋白質，由159個氨基酸殘基組成。生產過程中所用的所有試劑均為非動物源性。
AA Sequence:
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤0.001 ng/ml, corresponding to a specific activity of ≥1 x 109 units/mg.
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Research Interests:
Cancer
Diabetes / Weight Regulation
Immune System
Inflammation
Neurobiology
Proliferation
Stem Cells & Differentiation
Wound Healing
Transplantation
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Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.
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