Size??100ug
Cat code??200319
Species Cross-reactivity??H,M
Key Application??WB,IHC,ICC
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??Affinity purified
Isotype??IgG1
Molecular Weight??60kDa
Sensitivity??This antibody detects endogenous levels TBLR1 and does not cross-react with related proteins.
Immunogen??Purified recombinant human TBLR1 protein fragments expressed in E.coli.
UniProt Number??Q9BZK7
GeneBank ID??AF314544
Subcellular location??Nucleus
Formulation??Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername??C21; DC42; IRA1; FLJ12894
Gene_symbol??C21; DC42; IRA1; TBLR1
Summary??TBLR1 is an F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. It plays an essential role in transcription activation mediated by nuclear receptors and probably acts as an integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of the N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
UniPort summary  Function??F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, th ereby allowing cofactor exchange, and transcription activation.
Application Images :??
Western blot detection of TBLR1 antibody in Mouse brain,Mouse heart&K562 cell lysates using TBLR1 antibody (1:1000 diluted).
Predicted band size: 60KDa
Observed band size: 60Kda.
Immunocytochemistry of HeLa cells using anti- TBLR1 antibody diluted 1:150.
IHC of paraffin-embedded huma breast cancer using anti- TBLR1 diluted 1/500-1/1000