Anti-SFN Polyclonal Antibody
產品名稱： Anti-SFN Polyclonal Antibody
英文名稱： Anti-SFN Polyclonal Antibody
產品編號： K001908P
產品價格： null
產品產地： 北京
品牌商標： Solarbio
更新時間： 2026-04-10T09:02:23
使用范圍：
北京索萊寶科技有限公司
- 聯系人 : 索萊寶-龔思雨
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Anti-SFN Polyclonal Antibody
品牌：solarbio | 貨號：K001908P
英文名稱 Anti-SFN Polyclonal Antibody 別名 YWHAS 應用 WB IHC IF 稀釋比例 WB 1:500-2000. IHC 1:50-200. IF 1:50-200. 交叉反應 Human Mouse Rat 蛋白分子量 28kDa Gene ID 2810 保存 Store at -20°C. Avoid freeze / thaw cycles. 儲存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. 純化方法 Affinity purification 亞型 IgG 免疫原 Recombinant protein of human SFN 性狀 液體 Public Immunogen Range Recombinant protein of human SFN Subcellular Locations Cytoplasm Nucleus Secreted Swiss Prot P31947 克隆類型 Polyclonal Antibody 背景資料 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.