[KO Validated] IRF9 Rabbit pAb (APR24153N)
產品名稱： [KO Validated] IRF9 Rabbit pAb (APR24153N)
英文名稱： [KO Validated] IRF9 Rabbit pAb (APR24153N)
產品編號： APR24153N
產品價格： null
產品產地： 美國
品牌商標： Leading Biology
更新時間： null
使用范圍：
分子量：Calculated MW: 43kDa Observed MW: 43kDa 細胞定位：Cytoplasm, Nucleus 稀釋方法：WB 1:500 - 1:2000 總結：Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta. Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1 are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.