PeproTech大鼠抗人/小鼠CD45R (B220) Biotin
產(chǎn)品名稱： PeproTech大鼠抗人/小鼠CD45R (B220) Biotin
英文名稱： Anti-Human/Mouse CD45R (B220) Biotin
產(chǎn)品編號： 07131-30-500
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： USA
品牌商標(biāo)： peperotech(BioGems)
更新時間： null
使用范圍： 流式
美國PeproTech(派普泰克)公司中國代表處
- 聯(lián)系人 :
- 地址 :  江蘇省蘇州市工業(yè)園區(qū)星湖街218號A1北座4樓L03
- 郵編 : 215123
- 所在區(qū)域 : 江蘇
- 電話 : 點擊查看
- 傳真 : 點擊查看
- 郵箱 : peprotech.infochina@thermofisher.com
The RA3-6B2 monoclonal antibody specifically reacts with a 220 kDa exon A-restricted epitope on the extracellular domain of mouse CD45 glycoprotein. CD45R/B220 is expressed on all the development stages of B cells, and at a low level on plasma cells and a subset of memory B cells. Low levels of CD45R/B220 are also expressed by some activated T lymphocytes, natural killer cell progenitors in the bone marrow, lymphokine activated killer cells (LAK), T lymphocytes of lpr/lpr mutant mouse, apoptotic T cells of mice injected with bacterial superantigens, and macrophage progenitors in fetal liver. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The RA3-6B2 antibody inhibits in vivo B lymphocytes responses and enhances isotype switching during in vitro B lymphocyte responses.