Anti-FAS Polyclonal Antibody
品牌：solarbio | 貨號：K000322P
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商品品牌：
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選擇規格
K000322P-50ul
solarbio
50ul
960.00元
K000322P-100ul
solarbio
100ul
1600.00元
英文名稱
Anti-FAS Polyclonal Antibody
別名
ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6
應用
WB IHC
稀釋比例
WB 1:500-2000. IHC 1:50-100.
蛋白分子量
38kDa
Gene ID
355
保存
Store at -20°C. Avoid freeze / thaw cycles.
儲存液
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法
Affinity purification
亞型
IgG
免疫原
A synthetic peptide of human FAS
性狀
液體
Public?
Immunogen?
Range
A synthetic peptide of human FAS
Subcellular?
Locations
Cell membrane Secreted Single-pass type I membrane?
protein
Swiss Prot
P25445
克隆類型
Polyclonal Antibody
背景資料
The protein encoded by this gene is a member of the TNF-
receptor superfamily. This receptor contains a death?
domain. It has been shown to play a central role in the?
physiological regulation of programmed cell death, and?
has been implicated in the pathogenesis of various?
malignancies and diseases of the immune system. The?
interaction of this receptor with its ligand allows the?
formation of a death-inducing signaling complex that?
includes Fas-associated death domain protein (FADD),?
caspase 8, and caspase 10. The autoproteolytic processing?
of the caspases in the complex triggers a downstream?
caspase cascade, and leads to apoptosis. This receptor has?
been also shown to activate NF-kappaB, MAPK3/ERK1, and?
MAPK8/JNK, and is found to be involved in transducing?
the proliferating signals in normal diploid fibroblast and T?
cells. Several alternatively spliced transcript variants have?
been described, some of which are candidates for?
nonsense-mediated mRNA decay (NMD). The isoforms?
lacking the transmembrane domain may negatively?
regulate the apoptosis mediated by the full length isoform.