全身體積描記器-植物生理/動物生理毒理/實驗動物設備-儀器設備-生物在線
上海玉研科學儀器有限公司
全身體積描記器

全身體積描記器

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產品名稱： 全身體積描記器

英文名稱： Whole body plethysmography全身體積描記器

產品編號： Whole body plethysmography全身

產品價格： 0

產品產地： USA

品牌商標： Whole body plethysmography全身體積描記器

更新時間： 2023-08-17T15:24:17

使用范圍： null

上海玉研科學儀器有限公司
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Whole?body?plethysmography?is?an?application?whereby?ventilatory?parameters?are?measured?while?the?subject?is?conscious?and?unrestrained.?By?the?use?of?bias?airflow?supplies,?CO2?levels,?temperature?and?humidity?are?maintained?at?normal?levels?enabling?measurements?to?be?made?over?several?hours.

?

During?inspiration?there?is?a?slight?net?pressure?rise?within?theplethysmograph?due?to?increased?temperature?and?humidity?of?the?air?as?it?enters?the?subject’s?lungs?(gas?conditioning).?During?normal?breathing,?this?pressure?difference?is?directly?proportional?to?the?respiratory?pattern?of?the?subject,?allowing?the?researcher?to?measure?respiratory?rate?and?tidal?volume,?in?accordance?with?ICH?S7?Guidelines.



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The?system?is?commonly?used?in?airway?hyper-reactivity?studieswhere,?in?addition?to?changes?in?ventilatory?parameters,?valuable?data?can?obtained?

by?quantifying?changes?in?the?shape?of?the?respiratory?waveform,?e.g.,?Penh.?However,?it?should?be?noted?that?when?bronchoconstriction?is?present,?

the?respiratory?signal?is?dominated?by?the?effects?of?gas?compression?and?therefore?exact?measures?of?tidal?volume?can?not?be?determined.

?

Parameters?Measured?

·?Breathing?frequency

·?Tidal?volume?(during?normal?breathing)

·?Minute?volume

·?Penh?(enhanced?pause)

·?Inspiration?time

·?Expiration?time

·?Peak?inspiratory?flow

·?Peak?expiratory?flow

·?Explanation?and?more?parameters

?

Features?

·?Non-invasive

·?Real?time?tidal?volume?measurement?using?multiple?compensation?factors?(e.g.?Epstein?&?Epstein,?Drorbaugh?&?Fenn)

·?Real?time?environmental?monitoring?(atmospheric?pressure,?temperature,?humidity)

·?Subject?is?unrestrained?and?conscious

·?No?anaesthesia

·?Range?of?species?including?guinea?pigs,?rats?and?mice

·?Chronic?and?long?term?use

·?Measurement?during?aerosol?challenge

·Up?to?sixteen?animals?measured?simultaneously

·?Optional?body?temperature?measurement?through?telemetry

?

Uses?

·?Airway?hyper-reactivity?models

·?Late?phase?response?studies

·?Chronic?studies

·?Drug?screening

·?Toxicology?

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