Anti-Phospho-KIT(Tyr721) Polyclonal Antibody
產品名稱： Anti-Phospho-KIT(Tyr721) Polyclonal Antibody
英文名稱： c-Kit (phospho Y721);c-Kit (phospho Tyr721);p-c-Kit (Tyr 721);C Kit;c-Kit;CD 117;CD117;CD117 antigen;KIT;KIT_HUMAN;Mast/stem cell growth factor recept
產品編號： K009593P
產品價格： null
產品產地： 北京
品牌商標：
更新時間： 2026-07-02T10:39:01
使用范圍： ELISA IHC-P IHC-F Flow-Cyt IF
北京索萊寶科技有限公司
- 聯系人 : 索萊寶-龔思雨
- 地址 : 北京市北京經濟技術開發區環科中路16號26幢3層301
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Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.