重組人FGL1蛋白（Recombinant Human FGL1 Protein），GMP級

產品貨號：GMP-TL742

產品描述（Description）

Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1. The protective effect of fibrinogen-like protein 1 (FGL1) in liver injury has previously been reported. However, studies have shown that FGL1 may be a predictor of GC patients and atarget for GC therapy. Immunocytochemical studies revealed that fgl1 selectively binds to defective spermatozoa in the cauda epididymidis. Northern blot analysis and in situhybridization demonstrated the high expression of fgl1 in the principal cells of the proximal cauda epididymidis. Immunofluorescence analysis using mouse fibrotic lung tissues suggested that fibrotic regions showed increased expressions of Gtse1 and Fgl1, Gtse1 and Fgl1 are suggested to be novel targets for radiation-induced lung fibrosis.

分子別名（Synonym）

FGL1、Hepassocin、HP-041、HFREP-1、LFIRE-1、HFREP1

表達宿主（Expression host）

HEK293 細胞

來源（Source）

Human

蛋白序列（Protein Sequence）

DNA 序列編碼人 FGL1（Q08830-1）表達帶有 His 標簽在 C 末端

分子量（Molecular Weight）

重組人 FGL1 蛋白包含 295 個氨基酸，預測的理論分子量為 34kD

純度（Purity）

≥95%采用 SDS-PAGE 凝膠和高效液相色譜分析

內毒素（Endotoxin）

＜0.1EU/ug

生物活性（Biological Activity）

固定人 LAG-3（ Fc 標簽）的濃度是 20 μg/mL (100 μL/孔)能夠結合人 FGL1 (His 標簽)的線性范圍是 0-10ug/mL

穩定性（Stability）

凍干制劑可在4℃保存24個月，溶解后的液體可置于-20℃保存6-12個月，避免反復凍融

參考文獻

1、Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Wang Jun J, Sanmamed Miguel F MF, Datar Ila I, Su Tina Tianjiao TT, Ji Lan L, Sun Jingwei J, Chen Ling L, Chen Yusheng Y, Zhu Gefeng G .Cell 2019-01- 10 334-347.e12 1-2 176 DOI : 10.1002/smll.201802403 

2、Identification of molecular signatures involved in radiation-induced lung fibrosis.Jin Hee H, Kang Ga-Young GY, Jeon Seulgi S, Kim Jin-Mo JM, Park You Na YN, Cho Jaeho J. J. Mol. Med. 2019-01-01 37-47 197 

3、Fibrinogen? like? protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis.Zhang Yang Y, Qiao Hui-Xia HX, Zhou Yong-Tao YT, Hong Liang L.Mol Med Rep 2018-08-01 1465-1472 2 18

  注意：For research and manufacturing use.