Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several
piccolo-bassoon homology domains and C-terminal PDZ
and C2 domains (1, 2). In general it is found together
with bassoon, a related huge multi-domain protein of the
CAZ (cytoskeletal matric assembled at active zones) (3).
Piccolo is a scaffolding protein for proteins involved in
endo- and exocytosis of synaptic vesicles. Piccolo has
also been shown to interfere with clathrin medicated
endocytosis by binding to the F-actin and dynamin
binding protein Abp1 (2).