IGF-II, Human
產(chǎn)品名稱(chēng)： IGF-II, Human
英文名稱(chēng)：
產(chǎn)品編號(hào)： CB055-1702
產(chǎn)品價(jià)格： 0
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： ExCell Bio
更新時(shí)間： null
使用范圍： null
上海吉泰依科賽生物科技有限公司
- 聯(lián)系人 :
- 地址 : 上海市徐匯區(qū)桂平路481號(hào)18號(hào)樓5層
- 郵編 : 200233
- 所在區(qū)域 : 上海
- 電話 : 021-6439-8855 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : marketing@excellbio.com
Insulin-like Growth Factor II (IGF-II) is a single chain 7 kDa polypeptide, and shares a high degree of homology with insulin. During circulation in vivo, IGF-II is complexed to high affinity binding proteins, IGF Binding Proteins (IGFBP), which act as circulating reservoirs, transport IGF-II, and prolong the half life of IGF-II. The receptors of IGF-II (IGFRs) are transmembrane tyrosine receptors, and are heterotetrameric consisting of two α-subunits and two β-subunits. IGFRs execute their role via intracellullar signaling molecules, such as IRS, shc, and PI3K. The functions of IGF-II include promoting cell survival, growth, proliferation, differentiation and motility. In particular, IGF-II promotes proliferation, inhibits death, and stimulates transformation in breast cancer cells.
Recombinant human Insulin-like Growth Factor II (rhIGF-II) produced in E. coli is a single non-glycosylated polypeptide chain containing 68 amino acids. A fully biologically active molecule, rhIGF-II has a molecular mass of 7.6 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at ExCell Bio.