Size??100ug
Cat code??200873
Species Cross-reactivity??H
Key Application??WB
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??
Isotype??IgG2b
Molecular Weight??37kDa
Sensitivity??This antibody detects endogenous levels of IL18BP and does not cross-react with related proteins.
Immunogen??Purified recombinant human IL18BP protein fragments expressed in E.coli.
UniProt Number??O95998
GeneBank ID??NM_001145057
Subcellular location??Secreted
Formulation??ascites
Altername??I18BP_HUMAN;IL-18BP;IL18 BP;IL18 BPa;IL18BP;IL18BPa;Interleukin 18 binding protein;Interleukin-18-binding protein;MC51L 53L 54L homolog gene product;Tadekinig alfa;Tadekinig-alfa.
Gene_symbol??IL18BPa
Summary??The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine,IL18. It binds IL18,prevents the binding of IL18 to its receptor,and thus inhibits IL18-induced IFN-gamma production,resulting in reduced T-helper type 1 immune responses.This protein is constitutively expressed and secreted in mononuclear cells.Elevated level of this protein is detected in the intestinal tissues of patients with Crohn′s disease.Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq,Feb 2011]
UniPort summary  Function??Isoform A binds to IL-18 and inhibits its activity.Functions as an inhibitor of the early TH1 cytokine response.
Application Images :??
Western blot detection of IL18BP antibody in CHO-K1 cells transfected by IL18BP-PDGFR fusion protein and K562 cell lysates using IL18BP antibody (1:400-1:1000 diluted).Predicted band size:37KDa.Observed band size:37/40KDa.