CD38/ ADPRC1/ADPRC1/T10
產品名稱: CD38/ ADPRC1/ADPRC1/T10
英文名稱: CD38/ ADPRC1/ADPRC1/T10
產品編號: GMP-TL687
產品價格:
產品產地: China
品牌商標: 同立海源生物
更新時間: 2023-08-22T16:43:56
使用范圍: null
| 規格 | 價格 |
| 100μg | 5400.0 |
- 聯系人 : 崔女士
- 地址 : 北京市大興區中關村科技園區大興生物醫藥產業基地華佗路50號院13號樓
- 郵編 : 100085
- 所在區域 : 北京
- 電話 : 186****3653 點擊查看
- 傳真 : 點擊查看
- 郵箱 : cuilimei@seafrom.cn
重組人CD38 蛋白(Recombinant Human CD38 Protein),GMP級
產品貨號:GMP-TL687
產品描述(Description)
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP- ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
分子別名(Synonym)
ADPRC 1、 ADPRC1、 T10、cADPr hydrolase 1
表達宿主(Expression host)
HEK293 細胞
來源(Source)
Human
蛋白序列(Protein Sequence)
DNA序列編碼人CD38(UniProtKB/Swiss-Prot:Q01973)表達帶有Fc標簽在C末端
分子量(Molecular Weight)
重組人 CD38 蛋白 包含 489 個氨基酸,預測理論分子量為 56.8kD
純度(Purity)
≥95%采用 SDS-PAGE 凝膠和高效液相色譜分析
內毒素(Endotoxin)
<0.1EU/ug
生物活性(Biological Activity)
固定人 CD38(Fc Tag) at 1 ug/mL (100 uL/well) 能夠結合人源化抗 CD38 抗體的線性范圍是 1-5ng/mL
使用說明(Instructions)
穩定性和儲存:凍干的樣本的可以在4℃保存24個月,溶解后的液體可以于-20℃保存6-12個月,并且避免反復凍融
組成(Component)
含有6%甘露醇的無菌PBS(PH 7.4)的凍干粉
參考文獻
1、Pepys CD38 Controls the Innate Immune Response against Listeria monocytogenes. Timo Lischke, Kira Heesch, Valéa Schumacher, Michael Schneider, Friedrich Haag, Friedrich Koch-Nolte, Hans-Willi Mittrücker Infect Immun. 2013 Nov; 81(11): 4091–4099. doi: 10.1128/IAI.00340-13
2、Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion. James Boslett, Craig Hemann, Fedias L. Christofi, Jay L. Zweier Am J Physiol Cell Physiol. 2018 Mar 1; 314(3): C297–C309. Published online 2017 Nov 29. doi: 10.1152/ajpcell.00139.2017
注意:For research and manufacturing use.
