CD38/ ADPRC1/ADPRC1/T10-蛋白質/抗原/多肽-試劑-生物在線
北京同立海源生物科技有限公司
CD38/ ADPRC1/ADPRC1/T10

CD38/ ADPRC1/ADPRC1/T10

商家詢價

產品名稱: CD38/ ADPRC1/ADPRC1/T10

英文名稱: CD38/ ADPRC1/ADPRC1/T10

產品編號: GMP-TL687

產品價格:

產品產地: China

品牌商標: 同立海源生物

更新時間: 2023-08-22T16:43:56

使用范圍: null

規格 價格
100μg 5400.0
北京同立海源生物科技有限公司
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重組人CD38 蛋白(Recombinant Human CD38 Protein),GMP級

 

產品貨號:GMP-TL687


 

產品描述(Description)

 

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP- ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

 

 

 

分子別名(Synonym)

 

 ADPRC 1、 ADPRC1、 T10、cADPr hydrolase 1

 

 

 

表達宿主(Expression host)

 

HEK293 細胞

 

 

 

來源(Source)

 

Human

 

 

 

蛋白序列(Protein Sequence)

 

DNA序列編碼人CD38(UniProtKB/Swiss-Prot:Q01973)表達帶有Fc標簽在C末端

 

 

 

分子量(Molecular Weight)

 

重組人 CD38 蛋白 包含 489 個氨基酸,預測理論分子量為 56.8kD

 

 

 

純度(Purity)

 

≥95%采用 SDS-PAGE 凝膠和高效液相色譜分析

 

 

 

內毒素(Endotoxin)

 

<0.1EU/ug

 

 

 

生物活性(Biological Activity)

 

固定人 CD38(Fc Tag) at 1 ug/mL (100 uL/well) 能夠結合人源化抗 CD38 抗體的線性范圍是 1-5ng/mL

 

 

 

使用說明(Instructions)

 

穩定性和儲存:凍干的樣本的可以在4℃保存24個月,溶解后的液體可以于-20℃保存6-12個月,并且避免反復凍融

 

 

 

組成(Component)

 

含有6%甘露醇的無菌PBS(PH 7.4)的凍干粉

 

 


參考文獻


1、Pepys CD38 Controls the Innate Immune Response against Listeria monocytogenes. Timo Lischke, Kira Heesch, Valéa Schumacher, Michael Schneider, Friedrich Haag, Friedrich Koch-Nolte, Hans-Willi Mittrücker Infect Immun. 2013 Nov; 81(11): 4091–4099. doi: 10.1128/IAI.00340-13 

2、Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion. James Boslett, Craig Hemann, Fedias L. Christofi, Jay L. Zweier Am J Physiol Cell Physiol. 2018 Mar 1; 314(3): C297–C309. Published online 2017 Nov 29. doi: 10.1152/ajpcell.00139.2017




  注意:For research and manufacturing use.