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重組人可溶性CD14(Human sCD14,Human soluble CD14)

Wnt-3a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Expression of Wnt-3a occurs primarily along the dorsal midline across overlapping regions of the Central Nervous System (CNS). Wnt-3a signaling is essential for various morphogenetic events including embryonic patterning, cell determination, cell proliferation, CNS development, and cytoskeletal formation. Like other members of this family, Wnt-3a contains a highly conserved lipid modified cysteine rich domain that is essential for cell signaling. During a biochemical process called the canonical Wnt pathway; Wnt family members bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors to promote gene expression. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes and has shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Recombinant murine Wnt-3a is a monomeric glycoprotein containing 334 amino acid residues. Due to glycosylation, the murine Wnt-3a migrates at an apparent molecular weight of approximately 38.0-41.0 kDa by SDS-PAGE analysis under non-reducing conditions.?

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重組人可溶性CD14(Human sCD14,Human soluble CD14)

IL－2是一種淋巴因子，可提高人體對病毒、細(xì)菌、真菌、原蟲等感染的免疫應(yīng)答，使細(xì)胞毒性T細(xì)胞、 自然殺傷細(xì)胞和淋巴因子激活的殺傷細(xì)胞(LAK)增殖，并升高其余傷活性，進(jìn)而清除體內(nèi)腫瘤細(xì)胞和病毒感染細(xì)胞等，還可促進(jìn)干擾素、 腫瘤壞死因子等細(xì)胞因子的分泌和抗體產(chǎn)生。它是機(jī)體免疫應(yīng)答的核心物質(zhì)，是一種免疫增強(qiáng)劑，具有抗病毒、抗腫瘤和增強(qiáng)機(jī)體免疫功能等作用。最新研究證實(shí)：IL－2與內(nèi)源性腦啡肽具有共同的抗原決定簇和相似的空間結(jié)構(gòu)部份，故它能競爭結(jié)合到 中樞神經(jīng)系統(tǒng)中的阿片受體上，提高病閾，產(chǎn)生中樞及外周神經(jīng)鎮(zhèn)痛作用。它還可以在中樞神經(jīng)系統(tǒng)通過某種由阿片受體介導(dǎo)的通路對 交感神經(jīng)系統(tǒng)的興奮施加抑制性影響。

重組人可溶性CD14(Human sCD14,Human soluble CD14)?

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