The CD62L (HI62L) antibody recognizes a 76-kDa type-I transmembrane glycoprotein, L- selectin, also called leukocyte endothelial cellular adhesion molecule-1 (LECAM-1). CD62L is expressed on most peripheral blood T cells, B cells, some NK cells, monocytes and neutrophils. CD62L is also expressed on some splenic lymphocytes, bone marrow lymphocytes and myeloid cells, thymocytes and certain hematopoietic malignant cells. CD62L acts as the peripheral lymph node homing receptor, mediates lymphocytes homing to high endothelial venules (HEV) of peripheral lymphoid tissue and leukocytes rolling on activated endothelium at inflammatory sites.