Anti-Integrin beta 3(N-terminus)
產品名稱： Anti-Integrin beta 3(N-terminus)
英文名稱：
產品編號： 200395
產品價格： null
產品產地： 成都正能生物
品牌商標： Zen BioScience
更新時間： null
使用范圍： WB
- 聯系人 :
- 地址 : 中國成都高新區科園南路愛斯特大廈
- 郵編 : 610200
- 所在區域 : 四川
- 電話 : 180****2350 點擊查看
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- 郵箱 : sales@zen-bioscience.com
Size??100ug
Cat code??200395
Species Cross-reactivity??H
Key Application??WB
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??Affinity purified
Isotype??IgG1
Molecular Weight??110kDa
Sensitivity??This antibody detects endogenous levels of ITGB3 and does not cross-react with related proteins.
Immunogen??Purified recombinant human ITGB3 protein fragments expressed in E.coli.
UniProt Number??P05106
GeneBank ID??NM_000212
Subcellular location??Membrane; Single-pass type I membrane protein.
Formulation??Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Altername??BDPLT2;CD 61;CD61;CD61 antigen;GP3A;GPIIIa;GT;HPA 1;HPA 4;Integrin beta 3 (platelet glycoprotein IIIa antigen CD61);Integrin beta chain beta 3;Integrin beta-3;ITB3_HUMAN;ITG B3;ITGB 3;ITGB3;NAIT;Platelet fibrinogen receptor beta subunit;Platelet glycoprotein IIIa;platelet glycoprotein IIIa precursor;Platelet membrane glycoprotein IIIa;PTP;
Gene_symbol??GT; CD61; GP3A; BDPLT2; GPIIIa
Summary??The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
UniPort summary Function??Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi′s sarcoma lesions.
Application Images :??
Western blot detection of ITGB3 in 15ug & 25ug Leukocyte whole cell lysate(1:1000 diluted).Predicted band size:110KDa.Observed band size:110KDa.
