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Murine & Rat Growth Factors & Cytokines
Recombinant Murine IGF-I


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Synonyms :
Insulin-like Growth Factor-I, Somatamedin C, IGF-IA
Description :
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant murine IGF-I is a 7.6 kDa globular protein containing amino acids including 3 intra-molecular disulfide bonds.
Catalog #:
250-19
Source :
E.coli
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
The ED50 was determined a cell proliferation assay using FDC-P1 cells is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKAA 
PubMed Link :
IGF-1+AND+mouse
Country of Origin :
USA
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Size A
10μg
$80?
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Size B
50μg
$195?
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Size C
1mg
$1500?
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Special Sizes: 
Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures. 

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