Recombinant Mouse TPO (C-6His)
產(chǎn)品名稱： Recombinant Mouse TPO (C-6His)
英文名稱：
產(chǎn)品編號： CS59
產(chǎn)品價格： 0
產(chǎn)品產(chǎn)地： 中國
品牌商標： Novoprotein
更新時間： null
使用范圍： null
Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets.Mature mouse Tpo shares 71% and 81% aa sequence homology with human and rat Tpo, respectively. It is an 80-85 kDa protein that consists of an N-terminal domain with homology to Erythropoietin (Epo) and a C-terminal domain that contains multiple N-linked and O-linked glycosylation sites. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.