[KO Validated] SETD7 Rabbit pAb (APR28824N)
產(chǎn)品名稱： [KO Validated] SETD7 Rabbit pAb (APR28824N)
英文名稱： [KO Validated] SETD7 Rabbit pAb (APR28824N)
產(chǎn)品編號： APR28824N
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 美國
品牌商標(biāo)： Leading Biology
更新時間： null
使用范圍： WB (Human hepatocellular carcinoma cell line, Homo sapiens) IHC (Mus musculus, Rattus norvegicus) IF (Rattus norvegicus)
分子量：Calculated MW: 40kDa Observed MW: 48KDa 細(xì)胞定位：Chromosome, Nucleus 稀釋方法：WB 1:500 - 1:2000 IF 1:50 - 1:200 總結(jié)：Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.