ROCK1 polyclonal antibody
產品名稱： ROCK1 polyclonal antibody
英文名稱： ROCK1 polyclonal antibody
產品編號： PAB2021
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ROCK1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ROCK1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition.
Mammoto A, Huang S, Moore K, Oh P, Ingber DE.J Biol Chem. 2004 Jun 18;279(25):26323-30. Epub 2004 Apr 19.
- 2.
- Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.
Oi K, Shimokawa H, Hiroki J, Uwatoku T, Abe K, Matsumoto Y, Nakajima Y, Nakajima K, Takeichi S, Takeshita A.Arterioscler Thromb Vasc Biol. 2004 May;24(5):918-22. Epub 2004 Mar 25.
- 3.
- Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
Wang DS, Dou KF, Li KZ, Song ZS.World J Gastroenterol. 2004 Jan 15;10(2):299-302.
- Entrez GeneID:
- 6093
- Protein Accession#:
- NP_005397;Q13464
- Gene Name:
- ROCK1
- Gene Alias:
- MGC131603,MGC43611,P160ROCK,PRO0435
- Gene Description:
- Rho-associated, coiled-coil containing protein kinase 1
- Omim ID:
- 601702
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq
- Other Designations:
- OTTHUMP00000162514,p160-ROCK
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