ZMPSTE24 polyclonal antibody
產品名稱： ZMPSTE24 polyclonal antibody
英文名稱： ZMPSTE24 polyclonal antibody
產品編號： PAB11975
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ZMPSTE24.
- Immunogen:
- A synthetic peptide corresponding to amino acids 1-100 of human ZMPSTE24.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Primates, Zebra fish
- Specificity:
- This antibody is specific to ZMPSTE24.
- Form:
- Liquid
- Storage Buffer:
- In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.
Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG.Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13432-7. Epub 2007 Jul 25.
- 2.
- Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.
Young SG, Fong LG, Michaelis S.J Lipid Res. 2005 Dec;46(12):2531-58. Epub 2005 Oct 5.
- 3.
- Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24.
Corrigan DP, Kuszczak D, Rusinol AE, Thewke DP, Hrycyna CA, Michaelis S, Sinensky MS.Biochem J. 2005 Apr 1;387(Pt 1):129-38.
- Entrez GeneID:
- 10269
- Protein Accession#:
- O75844
- Gene Name:
- ZMPSTE24
- Gene Alias:
- FACE-1,FACE1,FLJ14968,STE24,Ste24p
- Gene Description:
- zinc metallopeptidase (STE24 homolog, S. cerevisiae)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq
- Other Designations:
- CAAX prenyl protease,OTTHUMP00000006394,farnesylated-proteins converting enzyme 1,prenyl protein-specific endoprotease 1,zinc metalloproteinase STE24