Size??100ug
Cat code??200822
Species Cross-reactivity??H,M
Key Application??WB,ICC
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??Affinity purified
Isotype??IgG1
Molecular Weight??48kDa
Sensitivity??This antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins.
Immunogen??Purified recombinant human TNFRSF10B protein fragments expressed in E.coli.
UniProt Number??O14763
GeneBank ID??NM_003842
Subcellular location??Membrane;Single-pass type I membrane protein.
Formulation??Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Altername??Fas like protein;Apoptosis inducing protein TRICK2A/2B;Apoptosis inducing receptor TRAIL R2;CD 262;CD262;CD262 antigen;Cytotoxic TRAIL receptor 2;Death domain containing receptor for TRAIL/Apo 2L;Death domain containing receptor for TRAIL/Apo2L;Death receptor 5;DR 5;DR5;Fas like protein precursor;KILLER;KILLER/DR5;OTTHUMP00000123492;OTTHUMP00000123493;p53 regulated DNA damage inducible cell death receptor (killer);p53 regulated DNA damage inducible cell death receptor(killer);TNF related apoptosis inducing ligand receptor 2;TNF related apoptosis inducing ligand receptor 2;TNF-related apoptosis-inducing ligand receptor 2;TNFRSF 10B;TNFRSF10B;TR10B_HUMAN;TRAIL R2;TRAIL receptor 2;TRAIL-R2;TRAILR2;TRANCER;TRICK2;TRICK2A;TRICK2B;TRICKB;Tumor necrosis factor receptor like protein ZTNFR9;Tumor necrosis factor receptor like protein ZTNFR9;Tumor necrosis factor receptor superfamily member 10b;Tumor necrosis factor receptor superfamily, member 10b;ZTNFR9.
Gene_symbol??DR5;CD262;KILLER;TRICK2;TRICKB;ZTNFR9;TRAILR2;TRICK2A;TRICK2B;TRAIL-R2;KILLER/DR5.
Summary??The protein encoded by this gene is a member of the TNF-receptor superfamily,and contains an intracellular death domain.This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand(TNFSF10/TRAIL/APO-2L),and transduces an apoptosis signal.Studies with FADD-deficient mice suggested that FADD,a death domain containing adaptor protein,is required for the apoptosis mediated by this protein.Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.[provided by RefSeq,Mar 2009]
UniPort summary  Function??Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Essential for ER stress-induced apoptosis.
Application Images :??
Western blot detection of TNFRSF10B antibody in Mouse kindey,Mouse brain,HCT116 and Hela cell lysates using TNFRSF10B antibody (1:500-1:2000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.
Immunocytochemistry of HeLa cells fixed by Paraformaldehyde and using anti-TNFRSF10B antibody diluted 1:100.