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Nedosiran

CAS No. : 2266591-83-5

MCE 國際站：Nedosiran

產品活性：Nedosiran (DCR-PHXC) 是一種靶向乳酸脫氫酶 (LDH) 的 RNA 干擾劑 (RNAi)。Nedosiran 可用于研究并發終末期腎病 (ESRD)的原發性高草酸尿癥 (PH)。Nedosiran 是一種 GalNAc-dsRNA 偶聯物。

研究領域：Epigenetics

作用靶點：Small Interfering RNA (siRNA)

In Vitro: Nedosiran (DCR-PHXC) is an investigational ribonucleic acid interference (RNAi) therapy.
Nedosiran is a synthetic, double-stranded RNA oligonucleotide (i.e., small interfering RNA [siRNA]) designed to target the mRNA encoding LDHA.

In Vivo: Nedosiran is a RNAi therapy for primary hyperoxaluria that selectively reduce hepatic expression of lactate dehydrogenase.
Nedosiran specially inhibits hepatic expression of lactate dehydrogenase (LDHA).
Nedosiran is a double-strand siRNA molecule that is conjugated with GalNAc, which takes advantage of the aforementioned unique asialoglycoprotein receptor (ASGPR) delivery system in the liver. Nedosiran is administered by monthly subcutaneous injection. Nedosiran decreases plasma oxalate in animal models.

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熱門產品線：重組蛋白? |? 藥物篩選? |? 天然產物? |? 熒光染料? |? PROTAC? |? 同位素標記物

Trending products：Recombinant Proteins? |? Bioactive Screening Libraries? |? Natural Products? |? Dye Reagents? |? PROTAC? |? Isotope-Labeled Compounds

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