TNNT2 Pre-design Chimera RNAi
產(chǎn)品名稱： TNNT2 Pre-design Chimera RNAi
英文名稱： TNNT2 Pre-design Chimera RNAi
產(chǎn)品編號： H00007139-R04
產(chǎn)品價格： 0
產(chǎn)品產(chǎn)地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍： null
亞諾法生技股份有限公司（Abnova)
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- 郵編 : 11493
- 所在區(qū)域 : 臺灣
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- Specification
- Product Description:
- Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 4, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_001001432
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 7139
- Gene Name:
- TNNT2
- Gene Alias:
- CMH2,CMPD2,MGC3889,RCM3,TnTC,cTnT
- Gene Description:
- troponin T type 2 (cardiac)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq
- Other Designations:
- OTTHUMP00000033864,OTTHUMP00000033867,cardiomyopathy, dilated 1D (autosomal dominant),cardiomyopathy, hypertrophic 2,troponin T type 2, cardiac,troponin T, cardiac muscle,troponin T2, cardiac
- Related Disease
- Cardiomegaly
- Cardiomyopathies
- Cardiomyopathy, Dilated
- Cardiomyopathy, Hypertrophic
- Cardiomyopathy, Hypertrophic, Familial
- Cardiovascular Diseases
- Death, Sudden, Cardiac
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Genetic Predisposition to Disease
- Hypertrophy, Left Ventricular
- Lipid Metabolism, Inborn Errors
- Mitochondrial Myopathies
- Tachycardia, Ventricular