SKA1 Antibody-抗體-抗體-生物在線

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深圳市豪地華拓生物科技有限公司
SKA1 Antibody

SKA1 Antibody

商家詢價

產品名稱: SKA1 Antibody

英文名稱: SKA1 Antibody

產品編號: 254143

產品價格: null

產品產地: 美國

品牌商標: Abbiotec

更新時間: null

使用范圍: E: 1:500-1:1,000; WB: 1:100-1:500

深圳市豪地華拓生物科技有限公司
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  • 郵編 : 518054
  • 所在區域 : 廣東
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Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs.  A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset.  Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure.  Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.