TP73 polyclonal antibody
產品名稱： TP73 polyclonal antibody
英文名稱： TP73 polyclonal antibody
產品編號： PAB10146
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against partial recombinant TP73.
- Immunogen:
- Recombinant GST fusion protein corresponding to C-terminus of TP73.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.08% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Western blot (5 to 10 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- p300 does not require its acetylase activity to stimulate p73 function.
Zeng X, Lee H, Zhang Q, Lu H.J Biol Chem. 2001 Jan 5;276(1):48-52.
- 2.
- The large T antigen of simian virus 40 binds and inactivates p53 but not p73.
Dobbelstein M, Roth J.J Gen Virol. 1998 Dec;79 ( Pt 12):3079-83.
- 3.
- The potential tumor suppressor p73 differentially regulates cellular p53 target genes.
Zhu J, Jiang J, Zhou W, Chen X.Cancer Res. 1998 Nov 15;58(22):5061-5.
- Application Image
- Western Blot
- Immunoprecipitation
- Entrez GeneID:
- 7161
- Gene Name:
- TP73
- Gene Alias:
- P73
- Gene Description:
- tumor protein p73
- Omim ID:
- 601990
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq
- Other Designations:
- OTTHUMP00000000662,p53-like transcription factor,p53-related protein
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Pancreatic Ductal
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- Cerebral Hemorrhage
- Chronic Disease
- Cleft Lip
- Cleft Palate
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Digestive System Neoplasms
- Disease Progression
- Endometrial Neoplasms