There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF hand containing
proteins required for the traffic of channel forming
Kv4 K+ subunits to the plasma membrane (3).
KChiP2 expression has been found to be significantly
decreased in hypertrophy and heart failure (4), and does so
thru modulatin of intracellular concentration and
calcineurin/NFAT pathways (4). It has also been found that
KChiP2 also functionally modulates the Cav1.2 governed Ltype
calcium channel through a direct interaction between
KChiP2 and the amino-terminus of Cav1.2 (5).