[KO Validated] Lamin A/C Rabbit pAb (APR23631N)
產品名稱： [KO Validated] Lamin A/C Rabbit pAb (APR23631N)
英文名稱： [KO Validated] Lamin A/C Rabbit pAb (APR23631N)
產品編號： APR23631N
產品價格： null
產品產地： 美國
品牌商標： Leading Biology
更新時間： null
使用范圍：
分子量：Calculated MW: 62-74kDa Observed MW: 63KDa/74KDa 細胞定位：Nucleus, Nucleus envelope, Nucleus lamina, Nucleus speckle, nucleoplasm 稀釋方法：WB 1:200 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 總結：The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.