Size??100ug
Cat code??200766
Species Cross-reactivity??H,Mk
Key Application??WB
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??null
Isotype??IgG1
Molecular Weight??72kDa
Sensitivity??This antibody detects endogenous levels of BIRC3 and does not cross-react with related proteins.
Immunogen??Purified recombinant c-IAP2 protein fragments expressed in E.coli
UniProt Number??Q13489
GeneBank ID??NM_001165
Subcellular location??Cytoplasm.Nucleus
Formulation??ascites
Altername??CIAP 2;Inhibitor of apoptosis protein 1;AIP 1;AIP1;API 2;API2;Apoptosis inhibitor 2;Baculoviral IAP repeat containing 3;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;C IAP2;CIAP 2;CIAP2;HAIP 1;HAIP1;HIAP1;IAP homolog C;IAP-1;Inhibitor of apoptosis protein 1;MALT 2;MALT2;Mammalian IAP homolog C;MIHC;MIHC;RING finger protein 49;RNF49;TNFR2 TRAF signaling complex protein 1;TNFR2 TRAF signalling complex protein;
Gene_symbol??AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; MALT2; RNF49; c-IAP2
Summary??This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases.The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione,a potent inducer of free radicals.It contains 3 baculovirus IAP repeats and a ring finger domain.Transcript variants encoding the same isoform have been identified.[provided by RefSeq,Aug 2011]
UniPort summary  Function??Multi-functional protein which regulates not only caspases and apoptosis,but also modulates inflammatory signaling and immunity,mitogenic kinase signaling and cell proliferation,as well as cell invasion and metastasis.Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions:acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1,RIPK2,RIPK3,RIPK4,CASP3,CASP7,CASP8,TRAF1,and BCL10.Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors(TLRs),Nodlike receptors (NLRs) and RIG-I like receptors (RLRs),collectively referred to as pattern recognition receptors (PRRs).Protects cells from spontaneous formation of the ripoptosome,a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Application Images :??
Western blot detection of BIRC3 in Ramos,COS7,Raji&Daudi cell lysates using BIRC3 antibody(1:1000 diluted).Predicted band size: 68KDa,Observed band size:72KDa