MPL purified MaxPab rabbit polyclonal antibody (D01P)
產品名稱： MPL purified MaxPab rabbit polyclonal antibody (D01P)
英文名稱： MPL purified MaxPab rabbit polyclonal antibody (D01P)
產品編號： H00004352-D01P
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against a full-length human MPL protein.
- Immunogen:
- MPL (NP_005364.1, 1 a.a. ~ 635 a.a) full-length human protein.
- Sequence:
- MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
- Host:
- Rabbit
- Reactivity:
- Human
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of MPL expression in transfected 293T cell line (H00004352-T01) by MPL MaxPab polyclonal antibody.
Lane 1: MPL transfected lysate(71.20 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 4352
- GeneBank Accession#:
- NM_005373
- Protein Accession#:
- NP_005364.1
- Gene Name:
- MPL
- Gene Alias:
- C-MPL,CD110,MPLV,TPOR
- Gene Description:
- myeloproliferative leukemia virus oncogene
- Gene Ontology:
- Hyperlink
- Gene Summary:
- In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq
- Other Designations:
- OTTHUMP00000008582,thrombopoietin receptor
- Related Disease
- Blast Crisis
- Bone Marrow Diseases
- Chronic Disease
- Disease Progression
- Genetic Predisposition to Disease
- Leukemia, chronic myeloid
- Leukemia, Megakaryoblastic, Acute
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Myelofibrosis
- Myeloproliferative Disorders
- Pancreatic cancer
- Pancreatic Neoplasms
- Polycythemia Vera
- Primary Myelofibrosis
- Thrombocythemia, Essential
- Thrombocythemia, Hemorrhagic
- Thrombocytosis