WASL (phospho Y256) polyclonal antibody
產品名稱： WASL (phospho Y256) polyclonal antibody
英文名稱： WASL (phospho Y256) polyclonal antibody
產品編號： PAB7899
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of WASL.
- Immunogen:
- Synthetic phosphopeptide (conjugated with BSA) corresponding to residues surrounding Y256 of human WASL.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- The human WASP sequence has a two amino acid difference in the same region surrounding tyrosine 291.
- Form:
- Liquid
- Storage Buffer:
- In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:20000)
Western Blot (1:10000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Focal adhesion kinase regulation of N-WASP subcellular localization and function.
Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL.J Biol Chem. 2004 Mar 5;279(10):9565-76. Epub 2003 Dec 15.
- 2.
- Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Torres E, Rosen MK.Mol Cell. 2003 May;11(5):1215-27.
- 3.
- Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway.
Baba Y, Nonoyama S, Matsushita M, Yamadori T, Hashimoto S, Imai K, Arai S, Kunikata T, Kurimoto M, Kurosaki T, Ochs HD, Yata J, Kishimoto T, Tsukada S.Blood. 1999 Mar 15;93(6):2003-12.
- Entrez GeneID:
- 8976
- Gene Name:
- WASL
- Gene Alias:
- DKFZp779G0847,MGC48327,N-WASP,NWASP
- Gene Description:
- Wiskott-Aldrich syndrome-like
- Omim ID:
- 605056
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq
- Other Designations:
- Wiskott-Aldrich syndrome gene-like,Wiskott-Aldrich syndrome gene-like protein,neural Wiskott-Aldrich syndrome protein