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MCE 10K Natural Product-like Compound Library

MCE 國際站：MCE 10K Natural Product-like Compound Library

Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways. MCE 10K Natural Product-like Compound Library consists of 10,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).

Description & Advantages:

????A unique collection of 10K natural product-like compound library.

????Each molecule contains scaffold of natural products or has a Tanimoto similarity coefficient greater than 0.6 with 40K natural products, and natural-likeness scoring is more than -2.

????Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2

???? Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

????All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

????NMR and HPLC validated to ensure high purity and quality.

品牌介紹:
????MCE (MedChemExpress) 擁有200 多種全球獨家化合物庫，我們致力于為全球科研客戶提供前沿最全的高品質小分子活性化合物；
????50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領域；
????產品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產品，廣泛應用于新藥研發、生命科學等科研項目；
????提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業技術服務；
????設有專業的實驗中心和嚴格的質控、驗證體系；
????提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
????產品的生物活性多經各國客戶實驗驗證；
????Nature, Cell, Science 等多種頂級期刊及制藥專利收錄了MCE客戶的科研成果；
????專業團隊跟蹤最新的制藥及生命科學研究進展，為您提供全球最新的活性化合物；
????與世界各大制藥公司及知名科研機構建立了長期的合作。