MYC (phospho S62) monoclonal antibody, clone 33A12E10
產品名稱： MYC (phospho S62) monoclonal antibody, clone 33A12E10
英文名稱： MYC (phospho S62) monoclonal antibody, clone 33A12E10
產品編號： MAB6763
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic phosphopeptide of MYC.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding S62 of human MYC.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG2b, kappa
- Storage Buffer:
- In antiserum (0.05% sodium azide)
- Storage Instruction:
- Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.
Khanna A, Bockelman C, Hemmes A, Junttila MR, Wiksten JP, Lundin M, Junnila S, Murphy DJ, Evan GI, Haglund C, Westermarck J, Ristimaki A.J Natl Cancer Inst. 2009 Jun 3;101(11):793-805. Epub 2009 May 26.
- 2.
- CIP2A inhibits PP2A in human malignancies.
Junttila MR, Puustinen P, Niemela M, Ahola R, Arnold H, Bottzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grenman R, Kast J, Kallunki T, Sears R, Kahari VM, Westermarck J.Cell. 2007 Jul 13;130(1):51-62.
- 3.
- Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.
Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR.Genes Dev. 2000 Oct 1;14(19):2501-14.
- Applications
- Western Blot (Transfected lysate)
- Western blot from crude cell extracts of AGS (gastric adenocarcinoma) cells with MYC (phospho S62) monoclonal antibody, clone 33A12E10 (Cat # MAB6763).
Lane 1 : Scrambled siRNA was introduced into the cells as a negative control.
Lane 2 : Negative control siRNA from Qiagen was transfected.
Lane 3 : siRNA for MYC was transfected.
The data was provided by A. Khanna and Dr. J. Westermark of University of Tampere.
- Entrez GeneID:
- 4609
- Gene Name:
- MYC
- Gene Alias:
- bHLHe39,c-Myc
- Gene Description:
- v-myc myelocytomatosis viral oncogene homolog (avian)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
- Other Designations:
- avian myelocytomatosis viral oncogene homolog,myc proto-oncogene protein,v-myc avian myelocytomatosis viral oncogene homolog
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