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Murine & Rat Growth Factors & Cytokines
Recombinant Murine IL-21





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		Synonyms :
none



		Description :
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation.  Its action generally enhances antigen-specific responses of immune cells.  The biological effects of IL-21 include induction of differentiation of T-cells-stimulated-B-cells into plasma cells and memory B-cells, stimulation (in conjunction) with IL-4 of IgG production, and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling.  Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells.  IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15.  The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.  Recombinant murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues.



		Catalog #:
210-21



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Determined by a cell proliferation assay using modified Ba/F3 cells.  The expected ED50for this effect is 10-50 ng/ml.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS 



		PubMed Link :
IL-21+AND+mouse


Country of Origin :
USA
















        Size A
2μg
$80?
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        Size B
10μg
$195?
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        Size C
1mg
$5200?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.