FIH 單克隆抗體: ATTO 488
產品名稱： FIH 單克隆抗體: ATTO 488
英文名稱： FIH Monoclonal Antibody: ATTO 488 [FIH 162c]
產品編號： SMC-182D-A488
產品價格： null
產品產地： 加拿大
品牌商標： StressMarq
更新時間： null
使用范圍： WB, Histology, Paraffin embedded, IF
StressMarq
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- 地址 : 加拿大
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- 郵箱 : hedyl@stressmarq.com
FIH, Factor inhibiting HIF1 (hypoxia-inducible factor), is an asparaginyl hydroxylase. FIH in conjunction with VHL represses HIF-1 transcriptional activity by disrupting the interaction of HIF-1 with the transcriptional co-activators CBP/p300, and by recruiting histone deacetylases. FIH activity is inhibited during hypoxia (1-3). Recent studies show that low nuclear expression of FIH is a strong independent prognostic factor for a poor overall survival in clear cell renal cell carcinoma (4).