BK channels contribute to electrical impulses, proper signal transmission of information and regulation of
neurotransmitter release (3). A gain of function mutation in
the pore-forming alpha subunit of the BK channel was linked
to human neurological diseases. Findings suggest that the
distribution of the beta subunits in the brain can modulate
the BK channels to contribute to the pathophysiology of
epilepsy and dyskinesia (4). This has major implications on
other physiological processes in tissues other than the brain.