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Human Growth Factors & Cytokines
Recombinant Human VEGF121





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		Synonyms :
Vascular Endothelial Growth Factor121, VPF



		Description :
VEGF is a potent growth and angiogenic cytokine.  It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability.  Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis.  VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.  Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates.  Recombinant human VEGF121 is a 28.4 kDa disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.



		Catalog #:
100-20A



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
PMAEGGGQNH HEVVKFMDVY QRSYCHPIET LVDIFQEYPD EIEYIFKPSC VPLMRCGGCC NDEGLECVPT EESNITMQIM RIKPHQGQHI GEMSFLQHNK CECRPKKDRA RQENCDKPRR 



		PubMed Link :
VEGF+AND+121


Country of Origin :
USA
















        Size A
2μg
$80?
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        Size B
10μg
$195?
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        Size C
1mg
$3900?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.