Product: Anti-ARMER (CT) pAb
Cat. No.: PC-463 (100 μg)
Synonyms:
ARL6 interacting protein, ARL61P, AIP1
Description:
Apoptosis is important for normal development
and tissue homeostasis. It is mediated by
various caspases and ultimately results in the
activation of endogenous endonucleases that
degrade cellular DNA. Although apoptosis
induced by endoplasmic reticulum (ER) stress is
thought to be mediated by caspase-12, other
caspases such as caspase-9 are also thought to
be activated following ER stress. Recently,
ARMER, a novel integral ER-membrane protein
was shown to protect cells from ER stressinduced
apoptosis. Analysis of the caspase
proteolytic cascade suggests that ARMER acts
by inhibiting caspase-9 activity, although the
mechanism for this remains unknown. It should
be noted that ARMER is not related to the
inhibitor of apoptosis proteins (IAP) family and
does not contain any baculo-viral IAP repeat
(BIR) domains.
Host:
Rabbit
Species Reactivity:
Human
Immunogen:
A peptide corresponding to 15 amino acids near
the C-terminus of human ARMER (GenBank
accession no. Q15041).
Format:
100 μg at 1 mg/mL of polyclonal IgG in PBS
containing 0.02% sodium azide. Ion-exchange
chromatography purified.
Storage:
Store at 4°C.
Applications:

Western blot: Use at 0.5 to 2 μg/mL.

Immunohistochemistry: Use at about 2
μg/mL with human bladder tissue.
The optimal dilution for a specific application
should be determined by the researcher.
Limitations:
For in vitro research use only. Not for use in
diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made
regarding the use of this product. KAMIYA
BIOMEDICAL COMPANY is not liable for any
damage, personal injury, or economic loss
caused by this product.