英文名稱
Neuropilin-1
中文名稱
神經纖毛蛋白1重組兔單克隆抗體
別????名
Neuropilin-1; NRP-1; Neuropilin1; BDCA4; CD 304; CD304; DKFZp686A03134; DKFZp781F1414; NEL like protein 1; Nel related protein 1; Neuropilin1; Neuropilin 1; Neuropilin1 transmembrane receptor; NP1; NRP 1; NRP; NRP1; OTTHUMP00000020818; OTTHUMP00000020820; OTTHUMP00000020821; Vascular endothelial cell growth factor 165 receptor; VEGF165R; A5 protein; BLOOD DENDRITIC CELL ANTIGEN 4; NRP1_HUMAN.??
研究領域
免疫學??神經生物學??生長因子和激素??細胞膜受體??內皮細胞??
抗體來源
Rabbit
克隆類型
Monoclonal
克?隆?號
49H9
交叉反應
(predicted: Human,?Mouse,?Rat,?)
產品應用
WB=1:1000-5000?IP=1:20-100?IHC-P=1:50-200?IHC-F=1:50-200?ICC=1:50-200?（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分?子?量
103kDa
細胞定位
細胞膜?分泌型蛋白?
性????狀
Liquid
濃????度
1mg/ml
免?疫?原
KLH conjugated synthetic peptide derived from human Neuropilin-1:?
亞????型
IgG
純化方法
affinity purified by Protein A
儲?存?液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed
PubMed
產品介紹
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Function:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Subunit:
Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Similarity:
Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.

SWISS:
O14786

Gene ID:
8829

Database links:
Entrez Gene: 8829?Human
Entrez Gene: 18186?Mouse
Entrez Gene: 246331?Rat
Omim: 602069?Human
SwissProt: O14786?Human
SwissProt: Q5T7F3?Human
SwissProt: P97333?Mouse
SwissProt: Q6PAR3?Mouse
SwissProt: Q9QWJ9?Rat
Unigene: 131704?Human
Unigene: 653996?Human
Unigene: 271745?Mouse
Unigene: 10815?Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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