脂聯素受體1(AdipoR1)抗體
產品名稱： 脂聯素受體1(AdipoR1)抗體
英文名稱： Adiponectin Receptor 1 antibody
產品編號： PR-1001
產品價格： null
產品產地： 江蘇
品牌商標： Hopebiot
更新時間： null
使用范圍： ELISA,WB,IHC,ICC,IP
- 聯系人 : 吳方
- 地址 : 江蘇省丹陽市呂城工業園
- 郵編 : 212300
- 所在區域 : 江蘇省
- 電話 : 189****1025 點擊查看
- 傳真 : 點擊查看
- 郵箱 : hopebiotech@163.com
Background:? Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Cloning of complementary DNAs encoding adiponectin receptors 1 (AdipoR1) has shown that AdipoR1 is abundantly expressed in skeletal muscle. This receptor is structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1 or suppression of AdipoR1 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. Widely expressed. Highly expressed in skeletal muscle. ADR 1 is expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
Description: Rabbit polyclonal to AdipoR1
Immunogen: KLH conjugated synthetic peptide derived from AdipoR1
Specificity: ?·Reacts with Human,
·Isotype: IgG
Application:? ·Western blotting: 1/500-1000. Predicted Mol wt: 41 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/200-500;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.