抗人Layilin/LAYN鼠單抗-抗體-抗體-生物在線

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北京義翹神州科技有限公司
抗人Layilin/LAYN鼠單抗

抗人Layilin/LAYN鼠單抗

商家詢價

產品名稱: 抗人Layilin/LAYN鼠單抗

英文名稱: Layilin Layilin LAYN

產品編號: 10208-MM01

產品價格: null

產品產地: 北京

品牌商標: 義翹神州(SinoBiologi

更新時間: null

使用范圍: western blot

北京義翹神州科技有限公司
  • 聯系人 :
  • 地址 : 北京亦莊東區科創十街18號院9號樓306室
  • 郵編 : 100176
  • 所在區域 : 北京
  • 電話 : 點擊查看
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  • 郵箱 : marketing@sinobiological.cn

官方網址:http://www.sinobiological.cn/Layilin-Antibody-g-948.html

Layilin Antibody Datasheet

Layilin抗體產品信息

免疫原 :

Recombinant human Layilin protein ( Catalog#10208-H08H )

Clone ID :

1G1G4B12

抗體宿主 :

Mouse? IgG1

緩沖液 : 0.2 μm filtered solution in PBS with 5% trehalose
制備方法 :

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human Layilin (rhLayilin; Catalog#10208-H08H; aa 1 - 220; NP_849156.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Layilin抗體使用指南

特異性 :

Human? Layilin

?

No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA.

Western blot : This antibody can be used at 1-2ug/mL with the appropriate secondary reagents to detect layilin in WB. Using a DAB detection system, the detection limit for Layilin is approximately 20ng/lane under reducing conditions. Use of this antibody under non-reducing conditions is not recommended.
儲存方法 : This antibody can be stored at 2℃-8℃ for 1 month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly.
Avoid repeated freeze-thaw cycles.

Layilin Antibody Related Products & Topics

相關研究領域:

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>Layilin

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Hyaluronic Acid Binding Protein>>Layilin

Immunology>>Adhesion Molecule>>Lectin>>Layilin

蛋白:

Molecule Species Description //For Detailed Info.------CLICK! Cat No
Layilin Human Layilin/Fc Protein, Recombinant 10208-H02H
Layilin Human Layilin Protein, Recombinant 10208-H08H

抗體:

Molecule Application Description //For Detailed Info.------CLICK! Cat No
Human
Layilin
WB Mouse Monoclonal Antibody 10208-MM01
Human
Layilin
ELISA Mouse Monoclonal Antibody 10208-MM02
Human
Layilin
WB, ELISA Rabbit Polyclonal Antibody 10208-RP01

Layilin Antibody Background

Layilin, a recently characterized transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions between the actin filaments and the cell membrane by binding to integral membrane proteins and to the cytoskeleton. Layilin is a newly identified membrane-binding site for talin in peripheral ruffles of spreading cells, and its adjacent LH2-LH3 tandem arrays in the cytoplasmic domain provide docking sites for talin. Layilin binds specifically to hyaluronan (HA) through its extracellular domain, a ubiquitous extracellular matrix component in most animal tissues and body fluids, but not to other tested glycosaminoglycans. In addition, merlin and radixin have been identified as different intracellular binding partners of Layilin. Accordingly, it has been suggested that Layilin plays roles in a variety of cellular processes, including cell shape, adhesion, motility, and homeostasis, as well as signal transduction. ? ?

參考文獻

1.? Rees, D.J.G. et al., 1990, Nature. 347: 685-689.

2.? Borowsky, M.L. et al., 1998, J. Cell Biol. 143: 429-442.

3.? Schoenwaelder, S.M. et al., 1999, Curr Opin Cell Biol. 11:274-286.

4.? Bono, P. et al., 2001, Mol. Biol. Cell. 12: 891-900.

5.? Bono, P. et al., 2005, Exp.Cell. Res. 308: 177-187.