Anti-P53(wt-p53) Polyclonal Antibody
產品名稱： Anti-P53(wt-p53) Polyclonal Antibody
英文名稱： Widespread p53;Wtp53;Antigen NY-CO-13;Cellular tumor antigen p53;Cys 51 Stop;HGNC11998;LFS1;p53;p53 Cellular Tumor Antigen;p53 Tumor Suppressor;Phosph
產品編號： K009544P
產品價格： null
產品產地： 北京
品牌商標：
更新時間： 2026-07-02T10:39:01
使用范圍： WB ELISA IHC-P IHC-F Flow-Cyt ICC IF
北京索萊寶科技有限公司
- 聯系人 : 索萊寶-龔思雨
- 地址 : 北京市北京經濟技術開發(fā)區(qū)環(huán)科中路16號26幢3層301
- 郵編 :
- 所在區(qū)域 : 北京
- 電話 : 181****6239 點擊查看
- 傳真 : 點擊查看
- 郵箱 : 3193328036@qq.com
- 二維碼 : 點擊查看
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.