阿培利司 Alpelisib 1217486-61-7
產品名稱： 阿培利司 Alpelisib 1217486-61-7
英文名稱： Alpelisib
產品編號： 1217486-61-7
產品價格： 0
產品產地： 國外
品牌商標： MEDKOO
更新時間： null
使用范圍： null
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Description:?Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Alpelisib is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM). eCollection 2020. Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth in vitro. Alpelisib Plus Letrozole Shows Promise After CDK 4/6 Inhibitor Therapy in PIK3CA-Mutated HR+/HER2- Advanced Breast Cancer.
CAS#: 1217486-61-7
Chemical Formula: C19H22F3N5O2S
Exact Mass: 441.14463
Molecular Weight: 441.47
Elemental Analysis: C, 51.69; H, 5.02; F, 12.91; N, 15.86; O, 7.25; S, 7.26
Synonym:?NVP-BYL719; NVP-BYL-719; NVP-BYL 719; BYL719; BYL-719; BYL 719; Alpelisib
IUPAC/Chemical Name:?(S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide.
InChi Key:?STUWGJZDJHPWGZ-LBPRGKRZSA-N
InChi Code:?InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
SMILES Code:?O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CC(C(C)(C)C(F)(F)F)=NC=C3)S2
Appearance:?white solid powder
Purity:?>98% (or refer to the Certificate of Analysis)
Shipping Condition:?Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:?Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:?Soluble in DMSO, not in water
Shelf Life:?>2 years if stored properly
Drug Formulation:?This drug may be formulated in DMSO
Stock Solution Storage:?0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code:?2934.99.9001