PeproTech重組人sTNF Receptor Type I(無(wú)動(dòng)物成分） 5ug
產(chǎn)品名稱(chēng)： PeproTech重組人sTNF Receptor Type I(無(wú)動(dòng)物成分） 5ug
英文名稱(chēng)： Human sTNF Receptor Type I
產(chǎn)品編號(hào)： AF-310-07-5
產(chǎn)品價(jià)格： 0
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： PeproTech（派普泰克）
更新時(shí)間： null
使用范圍： null
美國(guó)PeproTech(派普泰克)公司中國(guó)代表處
- 聯(lián)系人 :
- 地址 :  江蘇省蘇州市工業(yè)園區(qū)星湖街218號(hào)A1北座4樓L03
- 郵編 : 215123
- 所在區(qū)域 : 江蘇
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- 傳真 : 點(diǎn)擊查看
- 郵箱 : peprotech.infochina@thermofisher.com
Description: TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein. Manufactured using all Animal-Free reagents. Source:E.coli Synonyms:soluble Tumor Necrosis Factor Type I, TNFRSF1A, TNFAR, p60, p55, CD120a, TNFR1 AA Sequence:MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses. Biological Activity:Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-α, is 0.05 g/ml. Country Of Origin:USA Research Use Only: Not for use in diagnostic or therapeutic procedures.