Structure of 17-DMAG

17-DMAG
is a water soluble & cell-permeable analog of Geldanamycin and
17-AAG (1). It binds to the APTase site of human Hsp90a with high
affinity, has cytotoxic activity against many cancer cell lines (2), and
acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise
in preclinical models. 17-DMAG has excellent bioavailability, is widely
distributed to tissues, and is quantitatively metabolized much less than
is 17-AAG.

1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077.
2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381.
3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813.

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