隨著生命科學的不斷發展及對單細胞分析手段越來越高的需求,傳統的熒光流式細胞技術已不能滿足科學家們的需要。Fluidigm公司獨有的質譜流式技術（Mass Cytometry）應運而生。它通過對傳統流式技術和質譜技術的整合，是目前單細胞多參數分析中最先進的技術之一。它繼承了傳統流式細胞儀的高速分析的特點，又具有質譜檢測的高分辨能力，更高效、更易用，同時能夠更加深入地進行細胞表型、信號通路和功能的全面研究，是流式細胞技術一個新的發展方向。
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標題 |
刊物 |
發表時間 |
研究內容 |
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High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas |
Frontiers in Oncology |
Feb, 2020 |
彌漫性星形細胞瘤(DA)的免疫微環境特征研究 |
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A Carrier Strategy for Mass Cytometry Analysis of Small Numbers of Cells |
Methods Mol Biol |
Jan, 2020 |
Cytof技術檢測方法研究 |
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Phenotype molding of T cells in colorectal cancer by single-cell analysis |
Int J Cancer |
Jan, 2020 |
研究大腸癌中T細胞表型變化 |
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A comparison framework and guideline of clustering methods for mass cytometry data |
Genome Biol |
Dec, 2019 |
質譜流式數據聚類分析方法比較 |
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High-dimensional single-cell proteomics analysis reveals the landscape of immune cells and stem-like cells in renal tumors. |
J Clin Lab Anal |
Dec, 2019 |
不同類型腎腫瘤免疫細胞亞群分析 |
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A novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation. |
Blood Adv |
Dec, 2019 |
臍帶血移植恢復期，NK細胞多樣性及其對隨后復發的風險預測 |
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Application value of CyTOF 2 mass cytometer technology at single-cell level in human gastric cancer cells |
Exp Cell Res. |
Nov, 2019 |
CyTOF在胃癌研究中的應用價值 |
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Glutathione Might Attenuate Cadmium-Induced Liver Oxidative Stress and Hepatic Stellate Cell Activation |
Biol Trace Elem Res. |
Oct, 2019 |
鎘誘導的肝氧化應激和肝星狀細胞活化 |
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Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma. |
Cell Mol Immunol |
Oct, 2019 |
研究IL-38在過敏性哮*中的抗炎機制 |
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Single-cell mass cytometry reveals in vivo immunological response to surgical biomaterials |
Applied Materials |
Sep, 2019 |
應用質譜流式技術研究生物材料植入對免疫系統的影響 |
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A Mass-Ratiometry-Based CD45 Barcoding Method for Mass Cytometry Detection |
SLAS Technol |
Aug, 2019 |
Cytof細胞Barcode方法研究 |
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Immunomodulatory effect of mesenchymal stem cells in chemical-induced liver injury: a high-dimensional analysis |
Stem Cell Res Ther. |
Aug, 2019 |
MSCs肝損傷過程中的免疫調節作用 |
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The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer. |
Int J Radiat Oncol Biol Phys. |
Aug, 2019 |
RhoB信號通路與結直腸癌耐受放療機制研究 |
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Immunocyte Profiling Using Single-Cell Mass Cytometry Reveals EpCAM+ CD4+ T Cells Abnormal in Colon Cancer |
Front Immunol. |
Jul, 2019 |
研究結直腸癌患者PBMC的表型變化和免疫治療靶點的表達 |
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Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas |
Gut |
Jun, 2019 |
多組學HCC免疫微環境研究 |
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MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1 |
Gastroenterology. |
May, 2019 |
小鼠肝腫瘤對MET抑制劑耐藥機制研究 |
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Lymphocyte mass cytometry identifies a CD3-CD4+ cell subset with a potential role in psoriasis. |
JCI Insight |
Mar, 2019 |
銀屑病患者PBMC的免疫細胞亞群和信號通路分析 |
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Reduced CD27-IgD- B Cells in Blood and Raised CD27-IgD- B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease. |
Front Immunol. |
Mar, 2019 |
研究炎癥性腸?。↖BD）的腸內B細胞募集 |
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Ratiometric Barcoding for Mass Cytometry. |
Anal Chem. |
Sep, 2018 |
質譜流式技術barcoding方法 |
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Octaarginine-modified gold nanoparticles enhance the radiosensitivity of human colorectal cancer cell line LS180 to megavoltage radiation. |
Int J Nanomedicine. |
Jun, 2018 |
納米材料促進結直腸癌細胞系放射敏感度機制研究 |
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Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia |
J Transl Med |
Feb, 2018 |
阿帕替尼抗白血病機制研究 |
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The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. |
Nat Immunol. |
Jul, 2017 |
TAZ在 TH17和Treg分化過程中的作用 |
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Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer. |
Mol Cancer. |
Mar, 2017 |
PXR對奧沙利鉑的轉運作用及其引發的耐藥性機制研究 |
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Single cell proteomics in biomedicine: High-dimensional data acquisition, visualization, and analysis. |
Proteomics. |
Feb, 2017 |
數據分析方法研究 |