

神經退行性疾病是一類特定亞型神經元進行性丟失導致功能障礙的疾病,主要包括阿爾茨海默病、帕金森病、多發性硬化癥、肌萎縮側索硬化癥和共濟失調等疾病。目前這類疾病患者正在不斷增多,但能早期診治的患者比例少之又少,而利用神經疾病相關抗體有助于對該疾病做進一步研究,同時也有助于臨床的早期診斷和治療。

HSP70是一類分子伴侶,可以調控Tau、α-突觸核蛋白、TDP-43、朊蛋白和多聚谷氨酰胺蛋白的代謝進程,抑制神經退行性疾病中錯誤折疊蛋白質的聚集和毒性作用。
Preparation of photothermal responsive and ROS generative gold nanocages for cancer therapy.
Chemical Engineering Journal.
DOI: 10.1016/j.cej.2021.129744

文獻引用:(31篇)
Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling.
抗體介紹
Beclin-1是自噬中的重要角色,阿爾茲海默癥早期,Beclin-1在腦部病變區域中的表達是呈下降趨勢的,,研究表明該蛋白的表達會減少細胞內外的淀粉樣病變,而表達減少則會增加神經元內淀粉樣蛋白的聚集。因此,增加beclin-1水平可能成為潛在的AD的治療方案。
文獻引用:(20篇)
Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice.
RBM39 Alters Phosphorylation of c-Jun and Binds to Viral RNA to Promote PRRSV Proliferation.
文獻引用:(13篇)
Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression.Molecular Therapy-Nucleic Acids.
CDC42EP3 is a key promoter involved in the development and progression of gastric cancer.
Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation,and Nrf2 activation in a toxic model combining hyperglycemia+Aβ1-42 peptide in rat hippocampal neurons. Neurochemistry International.
Aqueous extract from You-Gui-Yin ameliorates cognitive impairment of chronic renal failure micethrough targeting hippocampal CaMKIIα/CREB/BDNF and EPO/EPOR pathways.
Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain.