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Small GTPases are a super-family of cellular signaling regulators. Rap family members (Rap1A, Rap1B, Rap2A, Rap2B,
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Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit.
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Heterotrimeric G proteins are critical cellular signal transducers. Gαs represents one sub-family of G proteins that could mediate the stimulation of adenylyl cyclases.
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Grb7 is an adaptor protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. It plays a role in the integrin signaling pathway and cell migration by
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Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate.
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The CASP8 gene encodes a member of the cysteine-aspartic acid protease (caspase) family.
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BMP3 belongs to the TGF-beta family. It negatively regulates bone density and antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and os
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Heterotrimeric G proteins are essential cellular signal transducers. Members (Gαq, Gα11, Gα14, Gα15 and Gα16) of the Gq sub-family of G proteins are known to stimulate phospholipas
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Ran (Ras-related nuclear protein) is a member of the Ras-superfamily GTPases. Ran is invovled in the transport of proteins across the nuclear envelope, as well as in microtubule
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MEK1 (also known as extracellular signal-regulated kinases
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